AIM To investigate the prevalence and association of Helicobacter pylori(H. pylori) with end-stage renal disease(ESRD).METHODS SA comprehensive literature search was completed from inception until October 2016. Studies that reported prevalence, relative risks, odd ratios, hazard ratios or standardized incidence ratio of H. pylori among ESRD patients were included. Participants without H. pylori were used as comparators to assess the association between H. pylori infection and ESRD. Pooled risk ratios and 95%CI was calculated using a random-effect model. Adjusted point estimates from each study were combined by the generic inverse variance method of DerS imonian and Laird.RESULTS Of 4546 relevant studies, thirty-seven observational studies met all inclusion criteria. Thirty-five crosssectional studies were included in the analyses to assess the prevalence and association of H. pylori with ESRD. The estimated prevalence of H. pylori among ESRD patients was 44%(95%CI: 40%-49%). The pooled RR of H. pylori in patients with ESRD was 0.77(95%CI: 0.59-1.00) when compared with the patients without ESRD. Subgroup analysis showed significantly reduced risk of H. pylori in adult ESRD patients with pooled RR of 0.71(95%CI: 0.55-0.94). The data on the risk of ESRD in patients with H. pylori were limited. Two cohort studies were included to assess the risk of ESRD in patients with H. pylori. The pooled risk RR of ESRD in patients with H. pylori was 0.61(95%CI: 0.03-12.20).CONCLUSION The estimated prevalence of H. pylori in ESRD patients is 44%. Our meta-analysis demonstrates a decreased risk of H. pylori in adult ESRD patients. AIM To investigate the prevalence and association of Helicobacter pylori (H. pylori) with end-stage renal disease (ESRD). METHODS SA comprehensive literature search was completed from inception until October 2016. Studies that reported prevalence, relative risks, odd ratios, hazard Rates or standardized incidence ratio of H. pylori among ESRD patients were included. Participants without H. pylori were used as comparators to assess the association between H. pylori infection and ESRD. Pooled risk ratios and 95% CI was calculated using a random-effect Thirty-five crosssectional studies were included in the analyzes to assess the prevalence and association of H. pylori with ESRD. The estimated prevalence of H. pylori among ESRD patients was 44% (95% CI: 40% -49%). The pooled RR of H. pylori in patients with ESRD was 0.77 (95% CI: 0.59-1.00) when compared with the patients without ESRD. Subgroup analysis showed significantly reduced risk of H. pylori in adult ESRD patients with pooled RR of 0.71 (95% CI: 0.55-0.94). The data on the risk of ESRD in patients with H. pylori were limited. Two Cohort studies were included to assess the risk of ESRD in patients with H. pylori. The pooled risk RR of ESRD in patients with H. pylori was 0.61 (95% CI: 0.03-12.20) .CONCLUSION The estimated prevalence of H. pylori in ESRD patients was 44%. Our meta-analysis demonstrates a decreased risk of H. pylori in adult ESRD patients.