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在氢氧化钾作用下,直接以不同种类氨基酸为亲核试剂,与手性(5S)-5-烷氧基-3,4-二卤-2(5H)-呋喃酮在室温下进行串联的不对称迈克尔加成-消除反应,合成了15个新的光学活性2(5H)-呋喃酮衍生物.通过旋光度,UV-Vis,IR,1H NMR,13C NMR,MS,元素分析和X射线单晶衍射等表征方法,确定了目标化合物的化学结构和绝对构型.
Under the action of potassium hydroxide, different kinds of amino acids were directly used as nucleophiles to react with chiral (5S) -5-alkoxy-3,4-dihalo-2 (5H) Fifteen novel optically active 2 (5H) -furanone derivatives were synthesized by asymmetric Michael addition-elimination reaction.The structures of the compounds were characterized by optical rotation, UV-Vis, IR, 1H NMR, 13C NMR, MS, elemental analysis and X-ray Single crystal diffraction and other characterization methods to determine the chemical structure of the target compound and the absolute configuration.