目的探讨不同热量的饲料喂养对肺癌荷瘤小鼠体内炎性微环境的影响。方法使用C57BL/6小白鼠,按照喂养饲料的不同进行分组,分为标准组、强化组、玉米组、脂肪乳组和高脂组,接种Lewis肺癌,各组以不同热量的饲料喂养至实验结束,处死取血清测肿瘤相关的炎性因子IL-6,IL-8,NF-KB,TNF-α。结果 5组动物的肿瘤相关炎性因子从低至高的排列为标准组<强化组<玉米组<脂肪乳组<高脂组。结论均衡营养更加有利于肺癌的荷瘤机体,过高或过低的热量饮食都不利于肺癌的生存,尤其是高脂肪饮食使体内促发肿瘤的炎性因子升高最为明显。营养损伤通过造成慢性炎症来引起或促发肺癌的发生和转移。 Objective To investigate the effects of different calorie-fed diets on inflammatory microenvironment in lung cancer-bearing mice. Methods C57BL / 6 mice were divided into three groups according to different feedstuffs: Lewis group, Lewis group, Lewis group, and control group. The mice in each group were fed with different calorie diet until the end of the experiment Serum samples were taken for determination of tumor-associated inflammatory cytokines IL-6, IL-8, NF-KB and TNF-α. Results The rank order of the tumor-associated inflammatory cytokines in the five groups was the standard group