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目的:探讨益气化湿胶囊对腺嘌呤肾衰大鼠肾脏功能及造血功能的影响。方法:取雄性SD大鼠50只,参照Yokozawa方法腺嘌呤300 mg/(kg.d)灌胃,连续25 d,建立腺嘌呤肾衰大鼠模型,观察口服益气化湿胶囊后肾衰大鼠红细胞脆性改变,以及甲状旁腺素、中分子物质、红细胞总数及血红蛋白、血清肌酐(SCr)、尿素氮(BUN)的含量变化。结果:益气化湿胶囊可以明显降低红细胞脆性的增加,抑制骨髓甲状旁腺素、血清SCr和BUN含量异常增加,降低血浆中分子物质含量和总量,提高红细胞总数及血红蛋白含量。结论:益气化湿胶囊对腺嘌呤肾衰大鼠血清SCr和BUN具有降低作用,对腺嘌呤肾衰大鼠造血功能改变具有调控作用。
Objective: To investigate the effects of Yiqi Huashi Capsule on renal function and hematopoietic function in rats with adenine-renal failure. Methods: Fifty male Sprague-Dawley rats were randomly divided into three groups: Adenine 300 mg / (kg.d) by Yokozawa method for 25 consecutive days. A rat model of adenine-induced renal failure was established. Changes of rat erythrocyte fragility, as well as parathyroid hormone, molecular substances, the total number of red blood cells and hemoglobin, serum creatinine (SCr), blood urea nitrogen (BUN) content changes. Results: Yiqi Huashi Capsule can obviously reduce the increase of erythrocyte fragility, inhibit the parathyroid hormone, the abnormal increase of serum SCr and BUN content, decrease the content of plasma molecular substance and total amount, increase the total number of red blood cells and hemoglobin content. Conclusion: Yiqi Huashi Capsule can reduce the serum levels of SCr and BUN in rats with adenine and renal failure, and regulate the hematopoietic function in rats with adenine and renal failure.