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目的比较三种不同全麻维持模式清醒时间，为临床选择一种最优良的全麻维持模式。方法90例16-90岁需全麻的择期手术病人随机分为3组。七氟烷维持组（S组）术中以3-4%七氟烷维持麻醉，丙泊酚维持组（P组）术中以100-120μg/kg.min持续泵注丙泊酚，七氟烷及丙泊酚序贯组（S+P组）诱导插管后维持同S组，手术后1/4段改为100-120μg/kg.min丙泊酚泵注，同时停吸七氟烷，以6L/min氧流量洗肺。比较3组病人停用麻醉药到呼唤睁眼的时间及苏醒期情况。结果 P组清醒时间明显小于S组和S+P组（均P <0.05）。恶心呕吐，烦躁的发生率三组比较无统计学差异（P＞0.05）。结论全麻维持使用丙泊酚较七氟烷及二者序贯苏醒快。“,”Objective To compare the awake time of three different maintainance mode of general anesthesia, then to choose the best one for clinical application. Methods ninety patients aged 16-90 yrs old undergoing elective surgery under general anesthesia were randomly divided into three groups .sevoflurane group(group S) received 3-4% sevoflurane for anesthesia maintainance; propofol group(group P) was pumped 100-120μg/kg.min propofol continuously; in sevoflurane and propofol group(group S+P) anesthesia were administered the same as group S after rapid induction and intubation,then received 100-120μg/kg.min propofol in latter 1/4 period of operation, at the same time stop inhalaing sevoflurane and wash the lung with 6L/min oxygen. The three groups’ awake time and side effects were compared. Results The awake time of group S is shorter than group P and group S+P (P <0.05). the incidence of nausea, vomiting, dysphoria in three groups have no significance . Couclusion the patients in group P recover faster than the other two groups.