论文部分内容阅读
目的探讨肝胆管结石合并肝内胆管癌的临床特点、诊断和治疗。方法总结2002年1月至2012年1月我院收治的46例经手术切除的肝胆管结石并发肝内胆管癌的临床资料。结果46例肝内胆管癌的发生率占同期肝胆管结石患者的3.9%(46/1186)。全组行根治性切除26例，姑息性切除14例，其1、3、5年生存率分别为92.3%、53.8%、30.8%和57.1%、14.3%、0，两者比较有显著性差异。结论长期肝胆管结石的刺激和胆道感染可致胆管癌的发生。详尽的影像学检查可提高术前诊断率，提高疗效的关键是早期诊断及争取根治性切除，姑息性切除可提高患者生活质量。“,”Objective:To discuss the clinical characteristics, diagnosis and treatment of hepatolithiasis complicated with cholangiocarcinoma.Methods:The clinical date of 46 patients of hepatolithiasis complicated with cholangiocarcinoma treated by excision between January 2002 and January 2012 in Fuzhou General Hospital were retrospectively analyzed.Results:The incidence of cholangiocarcinoma companying with hepatolithiasis was 3.9%(46/1186). Radical resection were performed in 26 patients, and pal iative operations were performed in 14 patients. 1,3 and 5 year survival rates of patients was about 92.3%、53.8%、30.8%;57.1%、14.3%、0 respectively, and they had significant difference between two groups. Conclusions:Long term recurrent irritation and infection after hepatolithiasis and is an important cause for the development of cholangiocarcinoma. Detailed imaging examination can improve the rate of preoperative diagnosis. The key to improve the therapeutic effectiveness is early diagnosis and striving for radical operation. Pal iative operation can improve the quality of live.