粒体DNA是细胞中唯一的核外遗传物质,当其发生突变时,可使线粒体氧化磷酸化产能障碍,ATP合成减少。肾小管上皮细胞的物质转运需要足够的能量供应,因此,线粒体DNA突变可通过影响上皮细胞的能量代谢而导致小管间质受损 Mitochondrial DNA is the only extranuclear genetic material in cells. When it is mutated, mitochondrial oxidative phosphorylation disability and ATP synthesis can be reduced. Substance transport by the tubular epithelial cells requires sufficient energy to supply, so that mitochondrial DNA mutations can damage the tubulointerstitium by affecting the energy metabolism of epithelial cells