应用放射免疫测定法测定了急性实验性脑缺血大白兔脑缺血前后血浆和脑脊液中强啡肽 A1-13样免疫活性物质(ir-Dyn A1-13)含量的变化。发现脑缺血后血浆和脑脊液中 ir-Dyn A1-13的含量明显升高(P<0.01);应用川芎治疗能显著地改善血浆和脑脊液中 ir-Dyn A1-13含量变化,并能显著地减轻大白兔脑组织缺血性损害和神经系统功能障碍。本文进一步探讨了脑缺血的病理生理机制及川芎防治脑缺血的作用机理。 The content of dynorphin A1-13-like immunoreactive substance (ir-Dyn A1-13) in plasma and cerebrospinal fluid was determined by radioimmunoassay in acute experimental cerebral ischemia rats. The level of ir-Dyn A1-13 in plasma and cerebrospinal fluid was significantly increased after cerebral ischemia (P<0.01); the use of Chuanxiong can significantly improve the plasma and cerebrospinal fluid levels of ir-Dyn A1-13, and can significantly Relieve ischemic brain damage and nervous system dysfunction in rabbits. This article further explored the pathophysiological mechanism of cerebral ischemia and the mechanism of action of Rhizoma Chuanxiong in preventing and treating cerebral ischemia.