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目的探讨东菱克栓酶(东菱迪芙)对急性缺血性卒中患者神经功能缺损评分的改善作用以及对纤维蛋白原和血小板的影响。方法将110例急性脑卒中病人随机分为治疗组80例与对照组30例。治疗组采用东菱迪芙治疗,对照组采用血塞通注射液治疗。两组病人分别在入院时、3周后进行神经功能缺损评分及纤维蛋白原、血小板的评定与检测,并在3月后进行神经功能缺损评分的随访,进行比较。结果东菱迪芙组在3周时(P<0.05)及3月时(P<0.01)神经功能缺损评分改善方面均优于对照组,3月时两组的有效率分别为93.75%和76.67%,治疗组更佳(P<0.01),3周时治疗组在降低纤维蛋白原方面优于对照组(P<0.01),对血小板计数无影响(P>0.05)。结论东菱迪芙对急性缺血性卒中患者有确切治疗作用。
Objective To investigate the effect of donglingkexin (Donglingdufu) on neurological impairment score in patients with acute ischemic stroke and its influence on fibrinogen and platelets. Methods A total of 110 acute stroke patients were randomly divided into treatment group (n = 80) and control group (n = 30). The treatment group was treated with Donglingdufu, while the control group was treated with Xuesaitong injection. Two groups of patients were admitted to hospital, 3 weeks after the neurological deficit score and fibrinogen, platelet assessment and testing, and neurological deficit scores were followed up after March for comparison. Results Compared with the control group, DFL group had better neurological deficit scores at 3 weeks (P <0.05) and 3 months (P <0.01), and the effective rates of the two groups were 93.75% and 76.67 %, The treatment group was better (P <0.01). At 3 weeks, the treatment group was superior to the control group in reducing fibrinogen (P <0.01), and had no effect on the platelet count (P> 0.05). Conclusion Donglingdufu has the exact therapeutic effect on acute ischemic stroke patients.