传统上危重病人须预防应急性溃疡,以免引起上消化道出血。近年自然历史对照研究表明出血并不多见,普遍性预防可能并不合理,呼吸功能衰竭和凝血病才是引起临床上严重出血的危险因素。随机试验表明,组胺 H_2受体阻滞剂和抗酸制剂可以预防严重的胃肠道出血,但亦有研究报道,胃内 PH 升高,有利于细菌生长并向气管内移位,引起院内肺炎。细胞保护制剂硫糖铝,不改变胃内 PH 值,相比而言,通气机相关肺 Traditionally, critically ill patients need to prevent acute ulcers, so as not to cause upper gastrointestinal bleeding. In recent years, natural history and control studies have shown that bleeding is rare, universal prevention may not be reasonable, respiratory failure and coagulopathy is the only cause of clinically significant bleeding risk factors. Randomized trials have shown that histamine H 2 receptor blockers and antacid preparations can prevent severe gastrointestinal bleeding, but studies have reported that elevated gastric pH is conducive to bacterial growth and translocation into the trachea, causing the hospital pneumonia. The cytoprotective agent sucralfate, which does not change the pH in the stomach, compared to ventilator-associated lungs