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目的：观察环氧化酶抑制剂阿斯匹林（Ａｓｐｉｒｉｎ，Ａｓｐ）对全肠外营养（ＴＰＮ）时蛋白质代谢的影响。方法：采用２８只腹腔感染大鼠，随机分成对照（ＴＰＮ组）和实验组（Ａｓｐ组）。每鼠每日均输注相同的全营养混合液（ＴＮＡ），Ａｓｐ组在ＴＮＡ中加入注射用赖氨匹林１５ｍｇ·ｋｇ－１·ｄ－１，实验持续４ｄ。实验前后测定体重、血清总蛋白、白蛋白、尿素氮和肌酐，每日测定氮平衡和尿３－甲基组氨酸（３－ＭＨ）的排出量，计算累积氮平衡和累积尿３－ＭＨ排出量。结果：Ａｓｐ组累积氮平衡显著优于对照组，累积尿３－ＭＨ排出比对照组显著减少。结论：阿斯匹林能改善感染时蛋白质代谢，减少蛋白质丢失。
Objective: To observe the effect of cyclooxygenase inhibitor Aspirin (Asp) on protein metabolism during total parenteral nutrition (TPN). Methods: Twenty-eight intraperitoneally infected rats were randomly divided into control group (TPN group) and experimental group (Asp group). The same total nutrient solution (TNA) was infused daily in rats. Asp group received 15 mg · kg-1 · d-1 of aspirin for injection in TNA for 4 days. Body weight, serum total protein, albumin, urea nitrogen and creatinine were measured before and after the experiment. Nitrogen balance and urinary 3-methyl histidine (3-MH) excretion were measured daily to calculate cumulative nitrogen balance and cumulative urinary 3-MH Emissions. Results: Asp cumulative nitrogen balance was significantly better than the control group, cumulative urinary 3-MH excretion than the control group was significantly reduced. Conclusion: Aspirin can improve protein metabolism during infection and reduce protein loss.