基因因素与BMD和骨量变异有关。基因对血清骨钙素和Ⅰ型前胶原的羧基末端多肽有很大影响;Vitamin D受体基因变异影响骨转化指标。骨激活激素如1,25(OH)_2D_3和雌二醇部分通过血管淋巴组织细胞对骨发挥作用。骨质疏松皮质骨内膜骨吸收和骨形成之间产生负平衡导致皮质骨丢失。机械力因素可刺激骨生长,维持骨强度和骨量,但其机理尚不清楚。(吴晶摘) Genetic factors and BMD and bone mass variation. Genes have a significant effect on serum osteocalcin and carboxy-terminal polypeptides of type I procollagen; mutations in the vitamin D receptor affect bone turnover. Bone-activating hormones such as 1,25 (OH) _2D_3 and the estradiol moiety play a role in bone via vascular lymphoid tissue cells. Negative balance between osteoporosis cortical endosteal bone resorption and bone formation leads to loss of cortical bone. Mechanical factors can stimulate bone growth, maintain bone strength and bone mass, but the mechanism is not clear. (Wu Jing picks)