论文部分内容阅读
目的探讨癌性锚蛋白重复序列(gann ankyrin repeats,gankyrin)蛋白在口腔鳞状细胞癌中的表达及临床意义。方法采用免疫组化方法检测55例口腔鳞状细胞癌组织及癌旁黏膜组织中gankyrin蛋白表达水平,观察口腔鳞状细胞癌不同临床病理特征下gankyrin蛋白的表达差异,分析其可能的临床价值。结果口腔鳞状细胞癌组织中gankyrin蛋白表达远高于癌旁黏膜组织(P=0.000)。高、中低分化鳞癌组间gankyrin蛋白表达差异有统计学意义(P=0.006);不同性别、年龄及有无淋巴结转移鳞癌组gankyrin蛋白表达差异无统计学意义。结论 Gankyrin蛋白高表达于口腔鳞状细胞癌,且与肿瘤分化程度相关。
Objective To investigate the expression and clinical significance of gann ankyrin repeats (gankyrin) protein in oral squamous cell carcinoma. Methods Immunohistochemistry was used to detect the expression of gankyrin in 55 cases of oral squamous cell carcinoma and para-cancerous mucosa. The expression of gankyrin protein in oral squamous cell carcinoma was observed under different clinicopathological features. The possible clinical value was analyzed. Results The expression of gankyrin protein in oral squamous cell carcinoma tissues was significantly higher than that in adjacent mucosa tissues (P = 0.000). There was significant difference in gankyrin protein expression between high and poorly differentiated squamous cell carcinoma (P = 0.006). There was no significant difference in gankyrin protein expression between squamous cell carcinoma of different sex, age and lymph node metastasis. Conclusion Gankyrin protein is highly expressed in oral squamous cell carcinoma and is related to the degree of tumor differentiation.