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我们测定了肝素单独应用及肝素分别与红比霉素、阿霉素联合应用在体外对兔结膜成纤维细胞的影响。证实肝素单独应用可明显抑制结膜成纤维细胞增殖,肝素的ID_(50)值为1.93mg/ml,肝素单独应用抑制成纤维细胞生长的效力比其与红比霉素或阿霉素联合应用的效力更大。肝素无明显副作用,有希望成为提高青光眼手术成功率的理想药物。
We measured the effects of heparin alone and heparin on the conjunctival fibroblasts in vitro in combination with neomycin and doxorubicin. Confirmed that heparin alone can significantly inhibit the proliferation of conjunctival fibroblasts, heparin ID_ (50) value of 1.93mg / ml, heparin alone fibroblasts inhibit fibroblast growth than its efficacy with the combination of red than doxorubicin or doxorubicin Greater effectiveness. Heparin has no apparent side effects and is promising as an ideal drug for improving the success rate of glaucoma surgery.