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目的了解胃癌患者及慢性萎缩性胃炎患者外周血中前列腺素E_2(PGE_2)的表达水平以及根除幽门螺杆菌后PGE_2的水平。方法收集50例胃癌患者及5_2例慢性萎缩性胃炎患者,采用ELISA法检测外周血中PGE_2的水平,对感染幽门螺杆菌的患者给予阿莫西林、雷贝拉唑、呋喃唑酮及胶体果胶铋抗HP治疗,检测根除幽门螺杆菌后患者外周血中PGE_2的水平,两两比较是否有统计学差异。结果胃癌患者外周血中PGE_2水平明显高于对照组,差异有统计学意义,分层分析,胃癌患者中,有幽门螺杆菌感染的患者外周血中PGE_2高于未感染者,根除幽门螺杆菌后外周血中PGE_2较根除治疗前明显降低,差异有显著性。慢性萎缩性胃炎患者中,根除幽门螺杆菌后,患者外周血中PGE_2水平也明显降低,较根除前有统计学差异。结论 HP感染可能促进PGE_2的表达,引起炎性反应。胃癌患者的PGE_2水平高于慢性萎缩性胃炎,为胃癌的早期筛查提供一定的依据。
Objective To investigate the expression of prostaglandin E_2 (PGE_2) in peripheral blood of patients with gastric cancer and chronic atrophic gastritis and the level of PGE_2 after the eradication of H. pylori. Methods 50 patients with gastric cancer and 5 2 patients with chronic atrophic gastritis were collected. The levels of PGE_2 in peripheral blood were detected by ELISA. Amoxicillin, rabeprazole, furazolidone and colloidal bismuth pectate were administered to patients with H. pylori infection HP treatment, detection of Helicobacter pylori eradication in patients with peripheral blood PGE 2 levels, any comparison of whether there is a statistically significant difference. Results The level of PGE_2 in peripheral blood of patients with gastric cancer was significantly higher than that of the control group. The difference was statistically significant. Stratified analysis showed that in patients with gastric cancer, PGE_2 was higher in patients with Helicobacter pylori infection than in non-infected patients. After H. pylori eradication Peripheral blood PGE_2 than before treatment significantly reduced, the difference was significant. In patients with chronic atrophic gastritis, the level of PGE_2 in peripheral blood of patients with eradication of H. pylori was also significantly lower than that before eradication. Conclusion HP infection may promote the expression of PGE_2 and cause inflammatory reaction. Gastric cancer patients with higher levels of PGE_2 than chronic atrophic gastritis, for the early screening of gastric cancer provide some evidence.