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目的 探讨IgE高亲和力受体 β链 (FcεRI β)基因启动子区 10 9C/T多态性与儿童哮喘血清总IgE水平的关系。方法 采用聚合酶链式反应 限制性片断长度多态性 (PCR RFLP)法检测了 2 0 0 1年 12月至 2 0 0 3年 2月吉林大学第一临床医院 12 6例哮喘儿童和 87名正常儿童的FcεRI β 10 9C/T基因多态性 ;用酶联免疫法检测血清总IgE水平和空气过敏原。结果 FcεRI β 10 9C/T基因型分布及等位基因频率哮喘组与正常对照组比较 ,差异均无显著性意义 ;哮喘组、对照组过敏原检测阳性率在突变基因型与未突变基因型间比较 ,差异均无显著性意义 ;哮喘组FcεRI β 10 9C/T突变纯合型个体的Log10 IgE水平高于突变杂合型及未突变型个体的水平 (P <0 0 5 )。结论 FcεRI β基因启动子区 10 9C/T不是汉族儿童哮喘的易感基因 ,与过敏原亦无关 ,但突变纯合子TT型与血清总IgE水平升高相关联。
Objective To investigate the relationship between the 109C / T polymorphism of IgE high affinity receptor β chain (FcεRI β) promoter and serum total IgE in childhood asthma. Methods 12 6 asthmatic children and 87 asthmatic children were enrolled in the First Clinical Hospital of Jilin University from December 2001 to February 2003 by polymerase chain reaction-restriction fragment length polymorphism (PCR RFLP) FcsRI β 10 9C / T gene polymorphism in normal children; total serum IgE levels and airborne allergens were detected by enzyme-linked immunosorbent assay. Results There was no significant difference in the distribution and allele frequencies of FcεRI β 10 9C / T between the asthma group and the normal control group. The positive rate of allergen in the asthma group and the control group was between the genotype of the mutant and the genotype of the non-mutated genotype (P <0.05). The Log10 IgE level of homozygous individuals with FcεRI β 10 9C / T mutation in asthma group was higher than that in heterozygous and non-mutated individuals (P <0.05). Conclusion The FcεRI β promoter region 109C / T is not a susceptible gene of Han children with asthma and has no relationship with allergens, but the mutant homozygote TT type is associated with elevated serum total IgE levels.