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一般情况下,由于芳胺中的芳香环进行酰化而制得氨基酮是不容易的。为此,以由四个磷酸分子失去四分子水所缩合而成的四偏磷酸(以下简称聚磷酸)为催化剂,将苯酰替苯胺(C_6H_5NHCOC_6H_5)与酰化剂苯(甲)酸酐加热至150℃反应三小时,即可制得4-氨基二苯甲酮,收率达84％。实例:在装有搅拌器、温度计的双颈圆底烧瓶中加入苯酰替苯胺100克(0.49摩尔)、苯(甲)酸酐80克(0.36摩尔)、聚磷酸800克,升温至150～155℃,加热三小时然后冷却至80℃。在搅拌下缓缓倾入1升水中。滤出析出的沉淀物,然后将其悬浮于250毫升40％氢氧
In general, it is not easy to prepare aminoketones due to acylation of aromatic rings in aromatic amines. To this end, four molecules of phosphoric acid (abbreviated as polyphosphoric acid) condensed by the loss of four molecules of molecular water are used as catalyst to heat the benzoylideneanilide (C_6H_5NHCOC_6H_5) and the acylating agent, benzoic anhydride to 150 ℃ reaction for three hours, 4-aminobenzophenone can be obtained in a yield of 84%. Example: In a two-necked round bottom flask equipped with a stirrer and a thermometer were charged 100 g (0.49 mol) of benzanilide, 80 g (0.36 mol) of benzene anhydride and 800 g of polyphosphoric acid and the temperature was raised to 150 to 155 ° C, heated for three hours and then cooled to 80 ° C. Slowly pour 1 liter of water while stirring. Precipitates were filtered off and then suspended in 250 ml of 40% hydrogen