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采用连续切片方法,分别测定35例Ⅲ期以内乳腺癌原发瘤至乳头及腋窝方向的浸润距离,采用免疫组化方法测定基质金属蛋白酶-9(MMP-9)在乳腺癌中的表达。发现至乳头方向浸润距离>0.5 cm的乳腺癌较至乳头方向浸润距离≤0.5 cm者有较高的MMP-9阳性表达率(P<0.05)。认为MMP-9可作为乳腺癌局部侵袭的标志物之一。
Using serial sections, the infiltration distance of 35 cases of primary tumor from breast cancer to the direction of the nipple and axilla were determined respectively. The expression of MMP-9 in breast cancer was detected by immunohistochemistry. Found that the infiltration of more than 0.5 cm in the direction of the nipple breast cancer breast cancer than the nipple direction infiltration distance ≤ 0.5 cm were higher MMP-9 positive expression rate (P <0.05). MMP-9 is considered as one of the markers of local invasion of breast cancer.