前列腺癌(PCa)是全球男性最常见的恶性肿瘤之一,同时也是癌症死亡的常见原因。如今血清标志物的检测已经在很大程度上提高了PCa的早期诊断,然而其潜在的分子机制一直没有完全被人们认识。长链非编码RNA(lncRNA)在PCa中的潜在作用体现在致癌和抑癌两个方面。LncRNA在绝大多数PCa中异常表达。本文将综述lncRNA在PCa中的异常表达,并讨论其在PCa的诊断、预测、预后、转移以及潜在临床治疗方面所扮演的新角色。 Prostate cancer (PCa) is one of the most common malignancies in men worldwide and is also a common cause of cancer deaths. Nowadays, the detection of serum markers has greatly improved the early diagnosis of PCa. However, the underlying molecular mechanism has not been completely recognized. The potential role of long chain non-coding RNA (lncRNA) in PCa is manifested in both oncogenic and anti-cancer aspects. LncRNA is abnormally expressed in most PCa. This article reviews the abnormal expression of lncRNA in PCa and discusses its new role in PCa diagnosis, prediction, prognosis, metastasis and potential clinical therapy.