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某些药物通过口腔粘膜给药可以迅速达到血药治疗浓度,避开肝脏首过作用,用作局部治疗时剂量小,副作用少,维持药效时间长,又便于中止给药。粘膜粘贴制剂技术研究的关键之一是选择合适的基质,要求该基质形态变化适宜,对粘膜有较强的粘着力,无刺激和能控制药物溶出等。本文将讨论某些材料在制作贴片时的一些特性。实验与结果一、实验材料聚羧乙烯(CVP934),羟丙基甲基纤维素(HPMC),甲基纤维素 M450(MC),羧
Certain drugs through the oral mucosa can quickly reach the concentration of plasma treatment, to avoid the first pass of the liver, for local treatment when the dose is small, less side effects, to maintain long-term efficacy, but also facilitate the suspension of administration. Mucosal sticking preparation technology research is one of the key to select the right matrix, requiring the substrate morphological changes appropriate, strong adhesion to the mucosa, no stimulation and can control drug dissolution. This article will discuss some of the properties of certain materials when making patches. Experimental and results First, the experimental materials Polycarboxylate (CVP934), hydroxypropyl methyl cellulose (HPMC), methyl cellulose M450 (MC), carboxyl