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血尿β_2微球蛋白(β_2-Microglobuln、β_2-MG)是评价肾小球滤过率(GFR)和肾小管功能的敏感指标。糖尿病人由于长期的代谢紊乱,常伴有肾脏损害。为探讨血尿β_2—MG测定在糖尿病肾病早期诊断中的价值,作者观察了40例Ⅱ型糖尿病病人血、尿β_2-MG的变化,现报告如下。对象:正常对照组40例(男19,女21)例,年龄18～40岁,平均31.5±6.7岁。均为献血员。糖尿病人40例(男10,女30),年龄35～92岁,平均60.3岁。病程0.5～18年。均为住院病人,经临床和实验检查确诊的非胰岛素依赖型糖尿病(NIDDM)。糖尿病诊断标准采用1985年WHO诊断标准。方法:受检者晨空腹采血,并于当日晨起排空膀胱后饮水500～1000ml,收集一小时内全部尿液,用放免法测定血尿β_2-MG。全部病人均同时测定血尿素氮(BUN)和肌酐(Cr)。统计分析采用t检验和x~2检验。结果:糖
Serum urinary β_2-microglobulin (β_2-Microglobulin, β_2-MG) is a sensitive index to evaluate glomerular filtration rate (GFR) and renal tubular function. Diabetic patients often suffer from kidney damage due to long-term metabolic disturbances. In order to investigate the value of β_2-MG determination of hematuria in the early diagnosis of diabetic nephropathy, the authors observed the changes of blood and urine β_2-MG in 40 cases of type 2 diabetic patients, the report is as follows. PARTICIPANTS: Forty patients (19 males and 21 females) in the normal control group were aged 18 to 40 years (mean, 31.5 ± 6.7 years). All blood donors. 40 cases of diabetes (male 10, female 30), aged 35 to 92 years, an average of 60.3 years old. Course of disease 0.5 to 18 years. All were hospitalized patients, clinically and experimentally confirmed non-insulin-dependent diabetes mellitus (NIDDM). Diabetes diagnostic criteria using the 1985 WHO diagnostic criteria. Methods: Subjects were fasting morning fasting blood, and on the day morning after emptying the bladder after drinking 500 ~ 1000ml, collecting all urine within one hour, using radioimmunoassay for determination of hematuria β_2-MG. All patients were simultaneously measured blood urea nitrogen (BUN) and creatinine (Cr). Statistical analysis using t test and x ~ 2 test. Results: Sugar