慢性阻塞性肺疾病(COPD)患者常合并营养不良,导致呼吸肌结构和功能受损,诱发感染,加重呼吸衰竭,使患者预后不良。合理的营养支持治疗可降低病死率,但能量代谢不平衡、缺氧、肿瘤坏死因子系统及血清瘦素等作用,可导致部分患者对营养支持无反应。因而抑制肿瘤坏死因子系统活性的药物可能成为治疗COPD合并难治性营养不良的新手段。 Chronic obstructive pulmonary disease (COPD) patients often associated with malnutrition, resulting in respiratory muscle structure and function damage, induced infection, aggravating respiratory failure, so that patients with poor prognosis. Reasonable nutrition support treatment can reduce mortality, but energy metabolism imbalance, hypoxia, tumor necrosis factor system and serum leptin and other effects, can lead to some patients did not respond to nutritional support. Thus, drugs that inhibit the activity of the tumor necrosis factor system may be a new treatment for refractory malnutrition in COPD.