细菌性脑膜炎,又称化脓性脑膜炎(以下简称化脑),在未用抗生素治疗以前,脑脊液可呈化脓性改变。典型的化脑在诊断上并非困难,但部分化脑的脑脊液可呈非典型改变,甚至正常,尤其是在疾病的早期。易致误诊,造成死亡。为了提高对非典型化的认识,参考有关文献,综述如下:一、脑脊液呈非典型改变的发生率和致病菌 Bacterial meningitis, also known as purulent meningitis (hereinafter referred to as brain), before treatment with antibiotics, cerebrospinal fluid can be purulent changes. The typical brain is not difficult to diagnose, but the cerebrospinal fluid of the partially brain may be atypically altered or even normal, especially in the early stages of the disease. Easy to cause misdiagnosis, resulting in death. In order to improve awareness of atypical, refer to the literature, reviewed as follows: First, the incidence of atypical cerebrospinal fluid changes and pathogens