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目的探讨子痫前期复发对妊娠结局的影响。方法回顾分析2009年1月至2014年3月在北京大学第三医院住院并分娩的有过子痫前期病史的临床观察病例资料82例,按照此次妊娠有无子痫前期复发分为复发子痫前期组(RPE组)37例和未复发子痫前期组45例(NRPE组),与同期无子痫前期病史此次妊娠初发子痫前期的病例90例(PPE组)进行比较,分析临床结局差异。结果 RPE组合并内科疾病者比例、合并慢性高血压者比例均明显高于NRPE组及PPE组(P<0.001、<0.001);RPE组子痫前期诊断孕周和妊娠分娩孕周均明显早于PPE组(P=0.009、0.037);RPE组轻度子痫前期者所占比例明显低于PPE组,早发型子痫前期者所占比例、慢性高血压合并子痫前期者所占比例均明显高于PPE组(P=0.015、0.004、<0.001);RPE组新生儿出生体重明显低于PPE组,小于孕龄儿比例、活产儿入住新生儿重症监护病房比例明显高于PPE组(P=0.048、0.034、0.015)。结论复发子痫前期较初发子痫前期有更严重的临床结局,母体存在更多的潜在病理状况。应注重复发子痫前期的防范,最大限度减少疾病复发,改善临床结局。
Objective To explore the influence of preeclampsia recurrence on pregnancy outcome. Methods A retrospective analysis of January 2009 to March 2014 in Peking University Third Hospital hospitalized and delivered pre-eclampsia clinical observation of 82 cases of clinical data, according to the pregnancy with or without preeclampsia recurrence is divided into recurrent 37 cases of preeclampsia group (RPE group) and 45 cases of non-recurrent preeclampsia group (NRPE group) were compared with 90 cases of preeclampsia without preeclampsia in the same period (PPE group) Differences in clinical outcome. Results The proportion of patients with RPE combined with medical diseases and the proportion of patients with chronic hypertension were significantly higher than that of NRPE and PPE groups (P <0.001, <0.001). The gestational weeks of preeclampsia and gestational gestational weeks in RPE group were significantly earlier than that of NRPE group and PPE group PPE group (P = 0.009, 0.037). The proportion of patients with mild preeclampsia in RPE group was significantly lower than that of PPE group, the proportion of premature preeclampsia and chronic hypertension with preeclampsia were significant (P = 0.015,0.004, <0.001). The birth weight of newborns in RPE group was significantly lower than that in PPE group, and the proportion of live births in neonatal intensive care unit was significantly higher than PPE group (P = 0.048, 0.034, 0.015). Conclusion Recurrence preeclampsia has more serious clinical outcomes than primary preeclampsia, and the mother has more potential pathological conditions. Should pay attention to the prevention of recurrent preeclampsia, minimize disease recurrence and improve clinical outcome.