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目的探讨人乳头状瘤病毒(HPV)感染和核转录因子(NF-кB)表达与卵巢上皮性肿瘤的关系,为临床治疗提供依据。方法选取2008年1月-2013年10月71例卵巢肿瘤患者的病理标本,检测卵巢上皮肿瘤组织HPV感染和NF-кB表达情况,分析与临床、病理的相关性。结果卵巢上皮癌患者HPV的阳性率要明显高于良性肿瘤患者,分别为36.73%、9.09%,差异有统计学意义(P<0.05);卵巢上皮癌患者NF-кBp65的阳性率较良性肿瘤患者明显升高,分别为69.39%、17.17%,差异有统计学意义;HPV感染在卵巢癌不同临床病理结果比较,差异无统计学意义;卵巢上皮癌患者的临床分期、病理分级及CA125值在不同等级NF-кB阳性率的比较,差异有统计学意义(P<0.05),病理分化程度越低、临床分期越晚及CA125值越高,NF-кB阳性率越高。结论 HPV感染和NF-кB的高表达与卵巢癌的发生有一定的关系,HPV感染患者应予积极治疗,以预防卵巢癌的发生。
Objective To investigate the relationship between human papillomavirus (HPV) infection and the expression of nuclear factor-kappa B (NF-κB) and epithelial ovarian tumor, so as to provide the basis for clinical treatment. Methods Totally 71 pathological specimens of ovarian tumors from January 2008 to October 2013 were collected to detect the HPV infection and the expression of NF-κB in ovarian epithelial tumor tissues. The correlation between the HPV infection and clinical and pathological features was analyzed. Results The positive rate of HPV in patients with epithelial ovarian cancer was significantly higher than that in benign tumors (36.73%, 9.09%, respectively) (P <0.05). The positive rate of NF-кBp65 in patients with epithelial ovarian cancer was significantly higher than that in patients with benign tumors (69.39%, 17.17% respectively), the difference was statistically significant. There was no significant difference in HPV infection among different clinical and pathological results in ovarian cancer. The clinical stage, pathological grade and CA125 in patients with epithelial ovarian cancer were different (P <0.05). The lower the degree of pathological differentiation, the later the clinical stage and the higher the CA125 value, the higher the positive rate of NF-κB was. Conclusion HPV infection and high expression of NF-кB have a certain relationship with the occurrence of ovarian cancer. Patients with HPV infection should be actively treated to prevent ovarian cancer.