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目的:探讨血清降钙素原(PCT)、超敏C-反应蛋白(His-CRP)对西宁地区重症患者的诊断、疗效观察中的应用价值。方法:选择我院呼吸科及ICU科收治的西宁地区重症肺炎32例,并与同期住院的非重症肺炎26例作为对照组,检测重症肺炎治疗前后及非重症肺炎血清PCT、His-CRP水平变化。结果:PCT、His-CR的敏感性及特异性均高,可作为评估治疗西宁地区重症肺炎的可靠指标;PCT、His-CRP治疗前后,治疗后与非重症肺炎比较有显著差异(P<0.01)。结论:PCT、His-CRP是评估治疗西宁地区重症的较好指标;PCT与His-CRP在患者经有效抗感染治疗后均可发生显著变化,联合检测PCT和His-CRP对西宁地区重症肺炎的疗效评估具有重要的临床意义。
Objective: To investigate the value of serum procalcitonin (PCT) and high-sensitivity C-reactive protein (His-CRP) in diagnosis and treatment of severe patients in Xining area. Methods: Thirty-two cases of severe pneumonia in Xining district were selected from Department of Respiratory Medicine and ICU, and 26 cases of non-severe pneumonia were hospitalized in the same period. The serum PCT and His-CRP levels were measured before and after severe pneumonia and non-severe pneumonia . Results: The sensitivity and specificity of PCT and His-CR were both high, which could be used as a reliable indicator to evaluate the treatment of severe pneumonia in Xining. The PCT and His-CRP were significantly different from those of non-severe pneumonia after treatment (P <0.01) ). Conclusion: PCT and His-CRP are good indicators for evaluating the severity of Xining. PCT and His-CRP may be significantly changed in patients after effective anti-infective treatment. Combined detection of PCT and His-CRP in severe pneumonia in Xining Efficacy evaluation has important clinical significance.