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目的采用行为药理学方法,探讨不同时期硬膜外地塞米松治疗对大鼠后足机械刺激疼痛阈值的影响,确定炎症和压迫因素的不同作用。方法取大鼠自体尾部椎间盘组织置于L5神经根下,建立椎间盘突出动物模型,然后硬膜外置管,采用早期预防性给药及晚期治疗性给药方法,观察地塞米松对大鼠后足底机械刺激疼痛阈值的影响。结果早期预防性硬膜外给予地塞米松完全抑制了大鼠2周内机械刺激疼痛阈值的降低,而3周时机械刺激阈值降到最低时治疗性硬膜外给予地塞米松对疼痛则无明显影响。结论椎间盘突出早期阶段,炎性反应是诱致疼痛的主要因素,硬膜外给予地塞米松可以抑制疼痛的产生;当椎间盘突出到达一定阶段,压迫因素成为致痛的主因时,硬膜外再给予地塞米松对已经产生的痛阈降低没有明显的缓解作用。
Objective To investigate the effects of epidural dexamethasone treatment on the pain threshold of mechanical stimulation of hindfoot in rats at different periods by behavioral pharmacology, and to determine the different effects of inflammation and oppression factors. Methods The autologous tail tissue of rats was placed under the L5 nerve root and the animal model of disc herniation was established. After the epidural catheter was administered, the prophylactic prophylaxis and late therapeutic administration were used to observe the effect of dexamethasone on the rat Effect of plantar stimulation on pain threshold. Results Early prophylactic epidural administration of dexamethasone completely inhibited the reduction of mechanical stimulus pain threshold within 2 weeks in rats, whereas the minimal mechanical stimulation threshold at 3 weeks reduced the pain to dexamethasone Clearly affected. Conclusion In the early stages of disc herniation, inflammatory reaction is the main factor inducing pain. Dexamethasone can inhibit the pain when epidural injection is given. When the disc herniation reaches a certain stage and the compression factor becomes the main cause of pain, Dexamethasone has no effect on reducing the pain threshold that has been produced.