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KATP通道是将细胞代谢与细胞电活动偶联在一起从而影响细胞功能的重要通道。ATP/ADP是主要的门控分子 ,对KATP通道开、关起至为重要的作用。膜磷脂 (PIP2 和PIP)通过拮抗ATP对通道的抑制作用 ,及细胞磷酸转移系统通过磷酸转移反应调节通道附近ATP/ADP比值 ,协助ATP/ADP对通道的调节。磺酰脲 (SUs)和钾通道开放剂 (COs)是一对作用相反的KATP通道外源性调节剂 ,作用位点在磺酰脲受体 (SUR)。信使系统 ,包括G蛋白 ,PKA ,PKG ,PKC分别对KATP通道起不同的调节作用。此外 ,细胞内代谢产物H+ 也参与通道调节。
KATP channel is the cell metabolism and cell activity coupled together to affect cell function of the important channels. ATP / ADP is the main gate molecule, KATP channel on and off to play an important role. Membrane phospholipids (PIP2 and PIP) assist in the regulation of ATP / ADP channels by antagonizing the inhibitory effect of ATP on the channel and by modulating the ATP / ADP ratio near the channel by the phosphorylation system. Sulfonylureas (SUs) and potassium channel openers (COs) are a pair of exogenous regulators of KATP channels that act in opposite directions and are active sites on the sulfonylurea receptor (SUR). Messenger systems, including G-protein, PKA, PKG and PKC play different regulatory roles on KATP channels. In addition, intracellular metabolites H + are also involved in channel regulation.