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目的:探讨环磷腺苷联合维生素C对小儿病毒性心肌炎患者的治疗效果及细胞免疫功能的影响。方法:病毒性心肌炎患儿96例,随机分成对照组和观察组各48例。对照组:接受病毒性心肌炎的常规治疗。观察组:接受病毒性心肌炎的常规治疗,同时给予维生素C和环磷腺苷治疗。结果:观察组总有效率高于对照组,差异具有统计学意义(P<0.01);观察组心电图总有效率高于对照组,差异具有统计学意义(P<0.01);治疗后,观察组CD3~+、CD4~+、CD8~+和NK水平均高于对照组,差异具有统计学意义(P<0.01);治疗后,观察组心肌酶指标乳酸脱氢酶、肌磷酸激酶、羟丁酸脱氢酶、谷草转氨酶、肌酸磷酸激酶均低于对照组,差异均有统计学意义(P<0.01);治疗后,观察组心功能指标CI、FS、EF水平都高于对照组,差异均有统计学意义(P<0.01)。结论:环磷腺苷联合维生素C治疗小儿病毒性心肌炎疗效确切,能够改善患者心脏功能,提高免疫功能。
Objective: To investigate the effect of cyclic adenosine monophosphate combined with vitamin C on the therapeutic effect and cellular immune function in children with viral myocarditis. Methods: 96 children with viral myocarditis were randomly divided into control group and observation group, 48 cases each. Control group: receiving routine treatment of viral myocarditis. Observation group: receiving conventional treatment of viral myocarditis, while giving vitamin C and cyclic adenosine monophosphate treatment. Results: The total effective rate in the observation group was higher than that in the control group (P <0.01), and the total effective rate in the observation group was higher than that in the control group (P <0.01). After treatment, the observation group The levels of CD3 ~ +, CD4 ~ +, CD8 ~ + and NK were higher than those in the control group (P <0.01). After treatment, the levels of myocardial enzymes such as lactate dehydrogenase, phosphokinase, Acid dehydrogenase, aspartate aminotransferase, creatine phosphokinase were lower than the control group, the difference was statistically significant (P <0.01); after treatment, the observation group of cardiac function index CI, FS, EF levels were higher than the control group, The differences were statistically significant (P <0.01). Conclusion: Cyclophosphamide combined with vitamin C treatment of children with viral myocarditis exact effect, can improve cardiac function and improve immune function.