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目的:通过检测实验性肝硬化各阶段三种内源性阿片肽(EOP)血浆浓度变化,探讨其与肝硬化高动力循环状态及腹水形成的关系.方法:应用放射免疫法测定了四氯化碳(CCl_4)诱发大鼠肝硬化过程中血浆三种EOP的含量变化.结果:结果显示肝硬化腹水组及肝硬化无腹水组血浆亮啡肽(L-ENK)、强啡肽(Dyn Al-13)含量均显著高于正常对照组(P<0.01,P<0.05),而且升高的水平与肝功能损害的程度呈显著正相关,但血浆β内啡肽(β-EP)的含量在三组中无显著差异(P>0.05).结论:提示肝脏灭活功能受损导致大鼠血浆小分子阿片肽含量升高,后者又是引起实验性肝硬化高动力循环及腹水形成的原因之一.
OBJECTIVE: To investigate the relationship between plasma concentrations of three endogenous opioid peptides (EOPs) and cirrhotic hyperdynamic circulation and the formation of ascites by detecting the levels of EOP in different stages of experimental cirrhosis.Methods: Radioimmunoassay Carbon tetrachloride (CCl_4) -induced changes in plasma levels of three EOP in cirrhotic rats.Results: The results showed that plasma levels of L-ENK and Dyn Al- 13) were significantly higher than that of the normal control group (P <0.01, P <0.05), and the level of the increase was positively correlated with the extent of liver dysfunction. However, the content of β-endorphin There was no significant difference between the three groups (P> 0.05) .Conclusion: It suggests that the impaired hepatic inactivation function leads to the increase of plasma small molecule opioid peptide in rats, which is also the reason of the formation of hyperdynamic circulation and ascites in experimental cirrhosis. one.