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IFN-β_2又名BSF-2,是由不同的淋巴组织及非淋巴组织产生的多功能细胞因子。最初发现有抗病毒活性,以后又发现有诱导人B 细胞生长和分化、促进小鼠浆细胞瘤和杂交瘤增殖、抑制成纤维细胞生长、诱导肝细胞合成某些“急性期”蛋白、诱导小鼠T细胞增殖分化为细胞毒T 细胞等活性。由于IFN-β_2/BSF-2具有多种活性,故将其命名为IL-6。本文报道了在PHA 或ConA 存在下,IFN-β_2/IL-6可促进人外周血T 细胞增殖,不需单核辅佐细胞参与直接作用于T 细胞,并提示主要作用于静止T 细胞。它诱导的T 细胞增殖不被IL-2受体的抗体所阻断,
IFN-β_2, also known as BSF-2, is a multifunctional cytokine produced by different lymphoid and non-lymphoid tissues. Initially found with antiviral activity, and later found to induce human B cell growth and differentiation, and promote the proliferation of mouse plasmacytoma and hybridoma, inhibition of fibroblast growth, induction of liver cells to synthesize some of the “acute phase” protein induced small Murine T cell proliferation and differentiation into cytotoxic T cells and other activities. Because IFN-β 2 / BSF-2 has multiple activities, it is named IL-6. This paper reports that IFN-β 2 / IL-6 can promote the proliferation of human peripheral blood T lymphocytes in the presence of PHA or ConA without the need of mononuclear adjuvant cells involved in the direct action of T cells, suggesting that they mainly act on resting T cells. It induced T cell proliferation is not blocked by IL-2 receptor antibodies,