在过饱和胆汁的模拟系统中,当加入由人血清提纯的浓度与人胆汁相同的脱脂脂蛋白A-1和A-2,可延长胆固醇-水合物的晶核(nucleation)过程。但脱脂脂蛋白C-3和其它血清蛋白则无此作用。由凝胶过滤层析法分级分离的人胆囊胆汁中,存在脱脂脂蛋白A-1和A-2,它对胆固醇结晶的晶核过程有强抑制作 In supersaturated bile simulation systems, the cholesterol-hydrate nucleation process can be extended by the addition of the skim lipoproteins A-1 and A-2 purified from human serum at the same concentrations as human bile. But skim lipoprotein C-3 and other serum proteins do not have this effect. Among the human gallbladder bile isolated by gel filtration chromatography, there are skim lipoproteins A-1 and A-2, which have a strong inhibitory effect on the crystal nuclei of cholesterol crystals