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目的：探讨氟伏沙明联合阿立哌唑治疗儿童少年强迫障碍的临床疗效和安全性。方法将80例儿童少年强迫障碍患者随机分为两组，每组40例，均口服氟伏沙明治疗，研究组在此基础上联合阿立哌唑治疗。观察8周。采用Yale-Brown强迫量表和副反应量表评定临床疗效和不良反应。结果治疗8周末，研究组显效率77．5％、总有效率92．5％，对照组分别为57．5％、87．5％，研究组显效率显著高于对照组（χ2＝4．53，P＜0．05）。两组不良反应均轻微，治疗各时段副反应量表评分比较差异均无显著性（P＞0．05）。结论伏氟沙明联合阿立哌唑治疗儿童少年强迫障碍起效快，疗效显著，安全性高，优于单用伏氟沙明治疗。“,”Objective To explore the efficacy and safety of aripiprazole plus fluvoxamine in the treatment of child and adolescent obsessive-compulsive disorder (OCD) .Methods Eighty OCD children and adolescents were randomly divided into two groups of 40 ones each ,both groups took orally fluvoxamine ,on this basis research group was plus aripiprazole for 8 weeks .Clinical efficacies were assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS ) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 8th week ,obvious and total effective rate were respectively 77 .5% and 92 .5% in research and 57 .5% and 87 .5% in control group ,obvious effective rate was significantly higher in the former than the latter (χ2 = 4 .53 ,P 0 .05) .Conclusion Fluvoxamine plus aripiprazole takes effect more rapidly , has an evident effect and higher safety compared with single fluvoxamine in the treatment of child and adolescent OCD .