【摘 要】
：
The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L.leaves (BCE) in type 2 diabetic mellitus (T2DM).Oral administration of BCE at doses of 70,140,and 280 mg·kg-1,to the normal rats and the high-fat-diet-and
【机 构】
：
State Key Laboratory of Natural Medicines, Department of Resources Science of Traditional Chinese Me
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The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L.leaves (BCE) in type 2 diabetic mellitus (T2DM).Oral administration of BCE at doses of 70,140,and 280 mg·kg-1,to the normal rats and the high-fat-diet-and streptozotocin-induced T2DM rats were carried out.Effects of BCE on blood glucose,body weight,and a range of serum biochemical parameters were tested,and histopathological observation of pancreatic tissues was also performed.HPLC-ESI-Q/TOF-MS/MS analysis indicated that the chemical composition of BCE mainly contained mangiferin,isoorientin,vitexin,isomangiferin,isovitexin,quercetin hexoside,2\'-trans-O-cumaroyl mangiferin,and nigricanside.BCE caused a significant decrease in the concentrations of fasting blood glucose,glycosylated hemoglobin,total cholesterol,triglyceride,low density lipoprotein-cholesterol,serum insulin,and malondialdehyde,and increases in oral glucose tolerance,high density lipoprotein-cholesterol,and superoxide dismutase in the T2DM model rats.Moreover,considerable pancreatic β-cells protection effect and stimulation of insulin secretion from the remaining pancreatic β-cells could be observed after BCE treatment.The results indicated that BCE exhibited an excellent hypoglycemic activity,and alleviated dyslipidemia which is associated with T2DM.Antioxidant activity and protecting pancreatic β-cells are the possible mechanisms involved in anti-diabetic activity of BCE.
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