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目的探讨胃肠道恶性肿瘤组织中磷脂酰肌醇3-激酶(PI3K)、蛋白激酶B(Akt)和细胞外信号调节蛋白激酶l/2(ERKl/2)的表达及意义。方法回顾性分析2011年8月至2013年6月间收治的50例胃肠道恶性肿瘤组织标本的临床资料。结果胃肠道恶性肿瘤组织中PI3K、Akt和ERKl/2的阳性表达率和免疫组化评分均明显高于癌旁组织,差异有统计学意义(P<0.05);患者年龄、病理类型、淋巴结转移、病理分期和远处转移情况与PI3K、Akt和ERKl/2的表达无显著相关(P>0.05)。结论胃肠道恶性肿瘤组织中PI3K、Akt和ERKl/2呈高表达,但与临床病理无关,可能参与肿瘤发生发展的早期事件。
Objective To investigate the expression and significance of phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and extracellular signal-regulated protein kinase 1 (ERKl/2) in gastrointestinal malignant tumors. Methods The clinical data of 50 specimens of gastrointestinal malignant tumors treated from August 2011 to June 2013 were retrospectively analyzed. Results The positive expression rates of PI3K, Akt and ERKl/2 in the gastrointestinal malignant tumor tissues and the immunohistochemistry scores were significantly higher than those in the adjacent tissues (P<0.05). The patients’ age, pathological type, lymph node The metastasis, pathological stage and distant metastasis were not significantly correlated with the expression of PI3K, Akt and ERKl/2 (P>0.05). Conclusion The expression of PI3K, Akt and ERKl/2 is high in gastrointestinal malignant tumors, but it has nothing to do with clinical pathology. It may be involved in the early events of tumor development.