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目的:探讨RUNX3(rs2236851,A→G)、SLC22A4(rs3792876,C→T)和PPAR-γ(rs3892175,A→G)基因的单核苷酸多态性(Single Nucleotide Polymorphism,SNP)与溃疡性结肠炎(ulcerativecolitis,UC)遗传易感性之间的关系。方法:选取经过临床表现、内镜、病理等方法共同确诊的UC患者81例,健康对照组154例,提取患者的全血基因组DNA,用聚合酶链反应序列特异性引物(PCR-SSP)的方法,检测UC患者、SLC22A4和PPAR-γ的基因型分布,并与健康对照组进行比较。结果:RUNX3的rs2236851位点的多态性与UC紧密相关(P<0.05);而SLC22A4的rs3792876位点与PPAR-γ的rs3892175位点的基因型分布与对照组相比,其差异无统计学意义(P>0.05)。结论:RUNX3的rs2236851位点的基因多态性为溃疡性结肠炎的遗传易感因素,而SLC22A4的rs3792876位点与PPAR-γ的rs3892175位点的基因多态性与溃疡性结肠炎的遗传易感性无关。
Objective: To investigate the relationship between Single Nucleotide Polymorphism (SNP) of RUNX3 (rs2236851, A → G), SLC22A4 (rs3792876, C → T) and PPAR-γ (rs3892175, A → G) The relationship between genetic susceptibility to ulcerative colitis (UC). Methods: Eighty-one UC patients and 154 healthy controls were enrolled in this study. The whole blood genomic DNA of patients were extracted and sequenced by polymerase chain reaction sequence-specific primers (PCR-SSP) Methods: The genotypes of UC patients, SLC22A4 and PPAR-γ were detected and compared with healthy controls. Results: The rs2236851 polymorphism of RUNX3 was closely related to UC (P <0.05). However, the genotype distribution of rs3792876 in SLC22A4 and rs3892175 in PPAR-γ was not statistically different Significance (P> 0.05). Conclusion: Genetic polymorphism of rs2236851 locus in RUNX3 is a predisposing factor for ulcerative colitis. Genetic polymorphisms of rs3792876 locus of SLC22A4 and rs3892175 locus of PPAR-γ may be associated with genetic predisposition to ulcerative colitis Sensual nothing to do.