糖尿病视网膜病变(DR)是糖尿病的重要并发症,其发病机制尚未完全明了。以往对DR的研究主要关注其血管病变,而近年来研究表明,在DR的视网膜血管病变发生之前,已有视网膜神经变性,包括视网膜神经元及神经胶质细胞的变性及丢失。Müller细胞作为视网膜最主要的神经胶质细胞,分布于整个视网膜,包绕视网膜上各级神经元的胞体、突起及视网膜血管[1]。Müller细胞不但可以影响视网膜 Diabetic retinopathy (DR) is an important complication of diabetes, the pathogenesis is not yet fully understood. In the past, the study of DR mainly focused on its vascular lesions. However, recent studies have shown that there are retinal neurodegeneration, including degeneration and loss of retinal neurons and glial cells, before the retinal vascular lesions of DR occur. Müller cells, as the most important glial cells in the retina, are distributed throughout the retina and surround the soma, protuberances and retinal vessels of neurons at all levels of the retina [1]. Müller cells not only affect the retina