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目的 验证树、熊猴感染人乙型肝炎 (乙肝 )病毒 (HHBV)血清感染指征。方法 用含HBV的人血清接种给 2 3 3只树 ,2 8只熊猴 ,每周定期采血 ,用不同公司生产的ELISA试剂检测接种后的动物血清感染指标。结果 树感染HHBV后 ,90 .0 %呈急性感染 ,44 .4%为可持续 1年以上的慢性感染 ,3 3 .3 %持续 2年 2个月。熊猴感染HBV后 ,血清HBV标志物呈一过性。结论 熊猴对HHBV并不敏感 ,而树对HHBV高度敏感 ,有望成为HHBV的动物模型。
Objective To verify the indications of seropositive hepatitis B virus (HHBV) infection in tree shrews and bears. Methods Serums of 2323 trees and 28 bears monkeys were inoculated with HBV-containing human serum and blood was collected regularly every week. Serum levels of serums from vaccinated animals were measured using ELISA reagents from different companies. Results 90% of cases were acutely infected after HHBV infection. 44.4% of them were chronic infections more than one year and 33.3% of patients were persistent for 2 years and 2 months. After the monkey infected with HBV, the serum HBV markers were transient. Conclusion The monkey is not sensitive to HHBV, while the tree shrew is highly sensitive to HHBV and is expected to be an animal model of HHBV.