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目的观察阿奇霉素静脉滴注所致的不良反应,为临床合理用药提供参考。方法回顾性分析我院2008年7月至2011年7月应用阿奇霉素治疗呼吸道感染疾病145例患者的临床资料。结果本组所有患者静脉滴注阿奇霉素后,有20例出现不良反应,累及全身多个系统,不良反应发生率为13.8%。其中以过敏反应最为常见,消化系统反应次之,其他依次为泌尿系统反应、循环系统反应、血液系统反应和运动系统反应。结论临床上应严格掌握适应证,重视对阿奇霉素不良反应的监测,严格控制药物浓度,降低滴注速度,尽量改为口服,可有效减少其不良反应的发生,以确保临床用药的安全性。
Objective To observe the adverse reactions caused by intravenous infusion of azithromycin and provide reference for clinical rational drug use. Methods A retrospective analysis of our hospital from July 2008 to July 2011 azithromycin treatment of respiratory tract infection in 145 patients with clinical data. Results All patients in this group after intravenous infusion of azithromycin, 20 cases of adverse reactions, involving multiple body system, the incidence of adverse reactions was 13.8%. Among them, the most common anaphylactoid reaction followed by the digestive system followed by urinary system reaction, circulatory system reaction, hematological system reaction and motor system response. Conclusion Clinical indications should be strictly controlled, the adverse effects of azithromycin should be monitored. Strict control of drug concentration and the speed of instillation should be taken. Oral administration can reduce oral adverse reactions and ensure the safety of clinical medication.