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本研究题目是结合我院药厂合成双安妥明药物需要1,3-丙二醇为原料而进行的,利用药厂生产的1,3-溴氯丙烷在碱性水溶液中水解法制备1,3-丙二醇,除考查了1,3-溴氯丙烷的水解工艺条件与中型生产试剂外,并进行了水解动力学的研究,测定了反应级数,得出在本实验条件下为假一级反应,而不同于一般伯仲卤代烃水解为二级反应的结论与文献报导不
The subject of this study was to combine 1,3-propanediol with 1,3-propanediol as the raw material in our hospital pharmaceuticals synthesis of 1,3-propanediol as the raw material, the use of pharmaceutical production of 1,3-bromochloropropane in aqueous alkaline hydrolysis of 1,3- Propylene glycol, in addition to examining the hydrolysis of 1,3-bromochloropropane process conditions and medium-sized production reagents, and the kinetic of hydrolysis was studied, the reaction order was determined in this experiment was pseudo-first-order reaction, And different from the general primary aromatic halogenated hydrocarbons hydrolysis reaction for the second conclusion and the literature does not report