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目的:探讨血必净在阻断老年急性脑出血伴全身炎症反应综合征(SIRS)患者向多器官功能障碍综合征(MODS)发展中的作用。方法:78例老年急性脑出血伴SIRS患者,随机分为治疗组40例和对照组38例,2组均给予常规治疗,治疗组加用血必净静脉滴注7d。观察患者的体温(T)、呼吸(RR)、心率(HR)、超敏C-反应蛋白(hs-CRP)、白细胞总数(WBC)、SIRS症状改善时间、MODS的发生率及30d死亡率。结果:治疗组T、RR、HR、hs-CRP及WBC改善情况显著优于对照组(P<0.05或P<0.01),进展为MODS者及30d死亡率均比对照组显著减少(P<0.05)。结论:血必净注射液能明显改善老年急性脑出血患者的SIRS症状。
Objective: To investigate the effect of Xuebijing in blocking the development of multiple organ dysfunction syndrome (MODS) in elderly patients with acute cerebral hemorrhage complicated with systemic inflammatory response syndrome (SIRS). Methods: Seventy-eight elderly patients with acute cerebral hemorrhage complicated with SIRS were randomly divided into treatment group (40 cases) and control group (38 cases). Both groups were given routine treatment. The treatment group was given Xuebijing intravenous infusion for 7 days. The patients’ body temperature (T), respiration (RR), heart rate (HR), high-sensitivity C-reactive protein (hs-CRP), total white blood cell count (WBC), symptom improvement time of SIRS, MODS incidence and 30d mortality were observed. Results: The improvement of T, RR, HR, hs-CRP and WBC in the treatment group was significantly better than that in the control group (P <0.05 or P <0.01), and those in the progression of MODS and 30d were significantly lower than those in the control group ). Conclusion: Xuebijing injection can significantly improve the symptoms of SIRS in elderly patients with acute cerebral hemorrhage.