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人类免疫球蛋白(Ig)根据其重链氨基酸排列顺序及二硫键位置的不同,分为IgG、IgG、IgA、IgM、IgD和IgE等5类,每类Ig都具有不同的抗原决簇,这种抗原决定簇即是同种异型的标记,它代表Ig的遗传多态性,可用血清学方法检出。 Gm、Km因子是Ig同种异型血清血型中的二个系统,目前国际上已检出的Gm因子有25个,Km因子有3个,这些因子的特异性取决于相应肽链的氨基酸排列次序。各种Gm因子一般都代有IgG_1和IgG_3上的因子组成单倍型传递。由于某些Gm因子只出现在某一人种和不
Human immunoglobulins (Ig) are classified into five categories, namely IgG, IgG, IgA, IgM, IgD and IgE according to the sequence of their heavy chain amino acids and disulfide bond positions. Each Ig has different epitopes, This antigenic determinant is the allotype of the marker, which represents the Ig genetic polymorphisms, available serological detection. Gm and Km factors are two systems of Ig allotype blood type. At present, there are 25 Gm factors and 3 Km factors detected in the world. The specificity of these factors depends on the amino acid sequence of the corresponding peptide chains . A variety of Gm factors on behalf of the generation of IgG_1 and IgG_3 factor haplotypes. Because some Gm factors appear only in one race and not