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目的：探讨功能性消化不良与抑郁情绪的关系及抗抑郁药对功能性消化不良的疗效。方法：用抑郁自评量表（Zung）标准分超过或等于50分作为确定抑郁状态依据，采用自身对照的临床研究，用抗抑郁药选择性5-羟色胺再摄取押制药（SSRI）治疗20例功能性消化不良患者4～6周．治疗前后进行Zung量表评分及症状评分。结果：150例内科住院病人（器质性疾病病人）中，有34％有抑郁情绪，其中50例器质性消化不良病人有24％有抑郁情绪。50例功能性消化不良病人有62％有抑郁情绪，三者相比具有显著性差异（P＜0．01）。20例功能性消化不良患者用SS－RI治疗4～6周后，Zung量表评分及症状评分前后对比具有显著性差异（P＜0．01）。结论：功能性消化不良与抑郁情绪关系密切，抗抑郁药能有效地改善功能性消化不良患者的症状。
Objective: To investigate the relationship between functional dyspepsia and depression and the effect of antidepressants on functional dyspepsia. Methods: Zung score of 50 or more was used as a basis for determining depression status. A self-controlled clinical study was conducted to treat 20 patients with anti-depressant selective serotonin reuptake drug (SSRI) Functional dyspepsia patients 4 to 6 weeks. Before and after treatment Zung scale score and symptom score. Results: Of the 150 inpatients (organic disease patients), 34% had depression, of which 24% had desensitization in 50 patients with organic dyspepsia. Fifty-two patients with functional dyspepsia had depression, 62% of which had significant difference (P <0.01). There were significant differences (P <0.01) between Zung scale score and symptom score in 20 patients with functional dyspepsia treated with SS-RI for 4 to 6 weeks. Conclusion: Functional dyspepsia is closely related to depression, antidepressants can effectively improve the symptoms of patients with functional dyspepsia.