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已知前列腺素在妊娠和产褥期具有生理学的作用,前列腺环素(PGI_2)和促血栓素(TxA_2)是强有力的血管活性物质.越来越多的证据证实其参与妊娠过程中各种病症的病理生理学.本文使用RIA确定整个妊娠期、产褥期PGI和TxA_2代谢物的相对值.研究包括155名妇女;其中正常非孕者49名,妊娠头3月29名,妊娠中3月31名,姬娠末3月29名,产后三天21名.取血样之前至少2周未服用阿斯匹林及其类似物.结果表明:妊娠头3月者血浆前列腺环素代谢物(PGI_2M)浓度明显高于妊娠中3月和妊娠末3月者:与非孕组比较有明显差别(P<0.01);而非孕组与
Prostaglandins are known to have physiological effects during pregnancy and puerperium, and PGI2 and TXA2 are potent vasoactive substances. There is a growing body of evidence that their involvement in various disorders during pregnancy Pathophysiology The RIA was used to determine the relative values of PGI and TxA 2 metabolites during pregnancy, puerperium, including 155 women, of whom 49 were non-pregnant, 29 were pregnant, 29 were pregnant, 31 were pregnant, 29 in the end of pregnancy and 21 in the third day after giving birth.Apirin and its analogues were not taken at least 2 weeks before the blood sample was taken.The results showed that the PGI2M concentration in the first trimester of pregnancy was significantly higher In the third trimester of pregnancy and the third trimester of pregnancy: Compared with the non-pregnant group, there was a significant difference (P <0.01); while the non-pregnant group