论文部分内容阅读
目的 探讨脂质过氧化(LPO)作用与围产儿预后的关系。方法 选择正常晚期妊娠妇女102例和妊娠期肝内胆汁瘀积症(ICP)患者126例。分别测定LPO和红细胞超氧化物歧化酶(RBC-SOD)活性;比较新生儿出生体重、Apgar评分和羊水状况。结果 ICP组母血LPO和RBC-SOD均明显高于对照组,二者呈显著正相关。在ICP组,宫内生长受限(IUGR)、新生儿窒息和羊水异常时,脐血LPO浓度均明显增高,而脐血RBC-SOD活性均明显下降。脐血LPO与新生儿出生体重和Apagr评分呈明显负相关。结论 LPO与ICP围产儿不良预后密切相关。
Objective To investigate the relationship between lipid peroxidation (LPO) and perinatal outcome. Methods One hundred and two cases of normal late pregnant women and 126 cases of intrahepatic cholestasis of pregnancy (ICP) during pregnancy were selected. The activities of LPO and erythrocyte superoxide dismutase (RBC-SOD) were measured respectively. The newborn’s birth weight, Apgar score and amniotic fluid status were compared. Results The levels of LPO and RBC-SOD in maternal blood in ICP group were significantly higher than those in control group, and there was a significant positive correlation between them. In the ICP group, intrauterine growth restriction (IUGR), neonatal asphyxia and amniotic fluid abnormalities, LPO concentrations in umbilical cord blood were significantly increased, while cord blood RBC-SOD activity were significantly decreased. Umbilical cord blood LPO and newborn birth weight and Apagr score was significantly negatively correlated. Conclusions LPO is closely related to the adverse prognosis of perinatal children.