虽然铋化合物用于治疗已有几个世纪,但铋在人体的药动学和血药浓度与毒性之间关系的资料公布得相当少。目前铋化合物主要是口服给药,在胃肠道起局部作用,吸收很少,血浓度一般低于限量。铋的药动学和药效学特性用图解示于图Ⅰ。已证明铋治疗消化性溃疡和腹泻有效。99％以上摄取的铋局部作用于胃肠道并由大便排出,然而对铋在全身循环的血浓度 Although bismuth compounds have been used for several centuries in the treatment, information on the relationship between bismuth pharmacokinetics and plasma concentrations and toxicity in the human body has been published relatively little. At present, bismuth compounds are mainly administered orally, which play a role in the gastrointestinal tract with little absorption, and the blood concentration is generally lower than the limit. The pharmacokinetic and pharmacodynamic properties of bismuth are schematically illustrated in Figure I. Bismuth has been shown to be effective in treating peptic ulcer and diarrhea. More than 99% of the uptake of bismuth locally acts on the gastrointestinal tract and is excreted by the stool, however, the concentration of bismuth in systemic circulation