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氯氮平（clozapine）届三环二苯氯氮平类药，是一种非经典神经阻滞剂，被认为是第四代抗精神病药。1历史回顾1960年于瑞士Wander药厂合成之后，Bente等发现氯氮平既没有抗抑郁作用，也没有锥体外系作用，而具有抗精神病作用。这一发现打破了传统的化学结构与精神药物相关的假说
Clozapine tricyclic benzodiazepine class of drugs, is a non-classical nerve blockers, is considered to be the fourth generation of antipsychotics. 1 History Review After the synthesis in Wander Pharmacy in Switzerland in 1960, Bente et al found that clozapine has neither antidepressant effect nor extrapyramidal action but antipsychotic effect. This finding breaks the hypothesis that traditional chemical structures are associated with psychotropic drugs