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目的旨在评价吸入外源性ＮＯ对几种主要内源性缩血管活性物质的影响。方法以烟雾吸入性损伤犬模型为研究对象，１７只犬随机分为２组，对照组（ｎ＝８）单纯吸氧（ＦｉＯ２，０．４５），治疗组（ｎ＝９）吸氧（ＦｉＯ２，０．４５）＋０．００４５％（４５×１０－６）ＮＯ，连续监测１２ｈ动脉血变化。数据进行多个样本均数间方差分析。结果伤后两组血浆内皮素（ＥＴｓ）、血管紧张素Ⅱ（ＡⅡ）、肾上腺素（Ｅ）和去甲肾上腺素（ＮＥ）含量均明显升高，治疗组在治疗开始后，与对照组相比均有不同程度降低，ＥＴｓ（Ｐ＜０．０５，０．０１），ＡⅡ（Ｐ＜０．０５，０．０１），Ｅ（Ｐ＜０．０５，０．０１），ＮＥ（Ｐ＜０．０１）。结论吸入外源性ＮＯ对内源性缩血管活性物质有不同程度抑制作用，提示临床应用吸入ＮＯ疗法应逐渐减量，以防发生反跳。
The purpose is to evaluate the effects of inhaled exogenous NO on several major endogenous vasoactive substances. Methods A total of 17 dogs were randomized into two groups: FiO2 (0.45) and FiO2 (n = 9) in the control group (n = 8) , 0.45) + 0.0045% (45 × 10-6) NO, continuous monitoring of 12h arterial blood changes. Data were analyzed for variance across multiple samples. Results The contents of plasma endothelin (ETs), angiotensin Ⅱ (AⅡ), epinephrine (E) and norepinephrine (NE) in the two groups were significantly increased after treatment. After treatment, (P <0.05, 0.01), AⅡ (P <0.05, 0.01), E (P <0.05, 0.01), NE (P < 0.01). Conclusion Inhalation of exogenous NO can inhibit endogenous vasoconstrictor activity to some degree, suggesting that the clinical application of inhaled NO therapy should be gradually reduced to prevent rebound.