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1例46岁男性患者因帕金森病服用多巴丝肼治疗,最初剂量为125 mg、3次/d,服用1年。因症状进行性加重,自行服用250 mg、4次/d,服用1.5年。之后,患者欲完全控制症状,再次自行将多巴丝肼剂量调整至125 mg/1.5 h(每日剂量达1375 mg)。约3个月后出现发作性左侧肢体不随意运动,停用多巴丝肼后上述症状逐渐减轻。停药第4天起再次给予患者多巴丝肼250 mg、4次/d口服,左侧肢体不自主抽动逐渐减少,1周后肢体抽动症状未发作。随访3个月未发作肢体不随意运动。
One 46-year-old male patient underwent dopamizine treatment with Parkinson’s disease at an initial dose of 125 mg three times daily for 1 year. Due to progressive worsening of symptoms, take their own 250 mg, 4 times / d, taking 1.5 years. Afterwards, the patient regained full control of the symptoms and again adjusted the dose of doxofos in to 125 mg / 1.5 h (daily dose of 1375 mg). About 3 months after onset of episodes of left limb involuntary movement, withdrawal of dopas hydrazide gradually reduce the above symptoms. On the fourth day after discontinuation, the patients were given oral administration of 250 mg of dobesidzine twice a day for 4 times a day. The involuntary left limb twitch decreased gradually. After 1 week, no symptoms of limb twitching occurred. 3 months follow-up did not attack limbs involuntary movement.