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目的 探索大鼠脊髓损伤所致神经源性肠功能障碍的肠道功能动态改变.方法 24只雌性Sprague-Dawley大鼠分为对照组(n=12)和脊髓损伤组(n=12).采用动脉瘤夹(标定力为70 g)钳夹60 s制作T10脊髓损伤模型;对照组只暴露硬脊膜.分别于造模前和造模后4周,X线造影观察肠道功能的动态改变,HE染色观察结肠病理改变.结果 与对照组相比,脊髓损伤组胃排空及肠道传输功能明显降低(P<0.05).结论 采用动脉瘤夹能成功复制大鼠脊髓损伤模型.大鼠脊髓损伤后出现神经源性肠功能障碍,胃排空及肠道传输功能明显减弱.“,”Objective To study the dynamic changes of the intestinal function of neurogenic bowel dysfunction rats caused by spi-nal cord injury using X-ray radiography. Methods Twenty-four female Sprague-Dawley rats were divided into control group (n=12) and spinal cord injury group (n=12). The T10spinal cord injury model was established using aneurysm clip (70 grams calibration force) for 60 seconds. The control group exposed the dura only. X-ray Barium was used to observe the dynamic changes of in-testinal function, and HE staining was used to observe the pathology of the colon before and four weeks after modeling. Results Compared with the control group, gastric emptying and intestinal transit function significantly reduced in the spinal cord injury group (P<0.05). Conclusion The spinal cord injury model can be successfully duplicated with aneurysm clip in rats; neurogenic bowel dysfunction occurs after spinal cord injury, gastric emptying and intestinal transit function are weakened.